Focus on Vastarel MR The metabolic approach to improving prognosis in ischemic heart disease
نویسنده
چکیده
Recent studies have demonstrated that alterations in cardiac metabolism can be present in ischemic heart disease and heart failure, suggesting an increased utilization of non carbohydrate substrates for energy production, with a reduction in the efficiency of myocardial oxygen consumption. A direct approach to the manipulation of cardiac energy metabolism consists in modifying substrate utilization. Trimetazidine is a pharmacological agent that shifts the preference for energy substrate away from fatty acid metabolism and towards glucose metabolism. Recent findings suggest that trimetazidine has a positive influence on ventricular function, various prognostic factors (inflammation and biochemical markers), and, probably, prognosis. Metabolic therapy offers concrete help in the management of coronary artery disease and dilated cardiomyopathy. Heart Metab. 2007;36:27–31.
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تاریخ انتشار 2007